Tirzepatide is administered via subcutaneous injection using a pre-filled pen or a single-dose vial with a syringe. It is typically injected:
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Once a week.
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At any time of day, with or without food.
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Into the thigh, abdomen, or upper arm.
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Alternate injection sites with each dose.
Your doctor will likely start you on a lower dose and may adjust it gradually, but not more frequently than every four weeks.
Insulin can be administered in the same area as tirzepatide, but the injections should be separate and not mixed in the same syringe.
Risks & Side Effects
Common Side Effects of Tirzepatide
Tirzepatide may cause several common side effects, such as abdominal discomfort, belching, constipation, diarrhea, indigestion, tiredness, acid reflux, hair loss, allergic reactions, injection site issues, nausea, and vomiting. These symptoms affect 5% or more of patients.
Serious Side Effects of Tirzepatide
Seek emergency medical attention if you experience:
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Signs of an allergic reaction, including hives, difficulty breathing, dizziness, or swelling of the face, lips, tongue, or throat.
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Symptoms of pancreatitis, which may involve severe upper stomach pain radiating to the back, nausea, and vomiting.
Contact your doctor immediately if you have:
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Severe abdominal issues.
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Vision problems or changes, such as blurred vision.
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Possible thyroid tumors, indicated by swelling or lumps in the neck, difficulty swallowing, a hoarse voice, or shortness of breath.
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Gallbladder issues, which may include pale stools, stomach pain after eating, nausea, heartburn, bloating, or severe upper stomach pain that may extend to the back.
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Symptoms of low blood sugar, including headache, hunger, weakness, sweating, confusion, irritability, dizziness, rapid heartbeat, or feeling jittery.
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Kidney problems, with symptoms such as reduced urination, swelling in the feet or ankles, fatigue, or shortness of breath.
Warnings
Tirzepatide may be associated with thyroid C-cell tumors. Inform your doctor if you have a personal or family history of thyroid cancer or Multiple Endocrine Neoplasia (MEN) syndrome, which causes tumors in endocrine glands. Contact your doctor right away if you experience any symptoms such as a neck lump or swelling, difficulty swallowing, hoarseness, or shortness of breath.
Ensure you attend all scheduled appointments with your healthcare provider and undergo any recommended tests to monitor your response to the medication.
Before Using Tirzepatide
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Notify your doctor and pharmacist if you have any allergies to tirzepatide, other medications, or the ingredients in this medicine.
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Inform your doctor if you have or have had kidney or pancreatic issues, diabetic retinopathy, or any digestive problems.
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Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding. If you become pregnant while on this medication, inform your doctor immediately.
How to Use Tirzepatide
Follow the instructions on your prescription label carefully and consult your pharmacist or doctor if anything is unclear. Use tirzepatide exactly as prescribed—do not alter the dosage or frequency.
